- 1 Welcome to the Cancer Deep Phenotype Extraction (DeepPhe) project
- 2 Who We Are
- 3 Funding
- 4 Publications and presentations crediting DeepPhe
- 5 DeepPhe Software
- 6 DeepPhe Gold Set
- 7 Qualitative Interviews
- 8 Project materials/ WIKIs to tasks
- 9 Communication
- 10 Scrum Sprints
- 11 Meeting Notes
- 12 Licensing
- 13 Contact
- 14 Getting started
Welcome to the Cancer Deep Phenotype Extraction (DeepPhe) project
Welcome to the Cancer Deep Phenotype Extraction (DeepPhe) project.
Cancer is a genomic disease, with enormous heterogeneity in its behavior. In the past, our methods for categorization, prediction of outcome, and treatment selection have relied largely on a morphologic classification of Cancer. But new technologies are fundamentally reframing our views of cancer initiation, progression, metastasis, and response to treatment; moving us towards a molecular classification of Cancer. This transformation depends not only on our ability to deeply investigate the cancer genome, but also on our ability to link these specific molecular changes to specific tumor behaviors. As sequencing costs continue to decline at a supra-Moore’s law rate, a torrent of cancer genomic data is looming. However, our ability to deeply investigate the cancer genome is outpacing our ability to correlate these changes with the phenotypes that they produce. Translational investigators seeking to associate specific genetic, epigenetic, and systems changes with particular tumor behaviors, lack access to detailed observable traits about the cancer (the so called ‘deep phenotype’), which has now become a major barrier to research.
We propose the advanced development and extension of a software platform for performing deep phenotype extraction directly from medical records of patients with Cancer, with the goal of enabling translational cancer research and precision medicine. The work builds on previous informatics research and software development efforts from Boston Children’s Hospital and University of Pittsburgh groups, both individually and together. Multiple software projects developed by our groups (some initially funded by NCI) that have already passed the initial prototyping and pilot development phase (eMERGE, THYME, TIES, ODIE, Apache cTAKES) will be combined and extended to produce an advanced software platform for accelerating cancer research. Previous work in a number of NIH-funded translational science initiatives has already demonstrated the benefits of these methodologies (e.g. Electronic Medical Record and Genomics (eMERGE), PharmacoGenomics Research Network (PGRN), SHARPn, i2b2). However, to date these initiatives have focused exclusively on select non-cancer phenotypes and have had the goal of dichotomizing patients for a particular phenotype of interest (for example, Type II Diabetes, Rheumatoid Arthritis, or Multiple Sclerosis). In contrast, our proposed work focuses on extracting and representing multiple phenotype features for individual patients, to build a cancer phenotype model, relating observable traits over time for individual patients.
Our first four development specific aims significantly extend the capability of our current software, focusing on challenging problems in biomedical information extraction. These aims support the development and evaluation of novel methods for cancer deep phenotype extraction:
Specific Aim 1: Develop methods for extracting phenotypic profiles. Extract patient’s deep phenotypes, and their attributes such as general modifiers (negation, uncertainty, subject) and cancer specific characteristics (e.g. grade, invasion, lymph node involvement, metastasis, size, stage)
Specific Aim 2: Extract gene/protein mentions and their variants from the clinical narrative
Specific Aim 3: Create longitudinal representation of disease process and its resolution. Link phenotypes, treatments and outcomes in temporal associations to create a longitudinal abstraction of the disease
Specific Aim 4: Extract discourses containing explanations, speculations, and hypotheses, to support explorations of causality
Our last two implementation specific aims focus on the design of the software to support the cancer research community, ensuring the usability and utility of our software. These aims support the design, dissemination and sharing of the products of this work to maximize impact on cancer research:
Specific Aim 5: Design and implement a computational platform for deep phenotype discovery and analytics for translational investigators, including integrative visual analytics.
Specific Aim 6: Advance translational research in driving cancer biology research projects in breast cancer, ovarian cancer, and melanoma. Include research community throughout the design of the platform and its evaluation. Disseminate freely available software.
Impact: The proposed work will produce novel methods for extracting detailed phenotype information directly from the EMR, the major source of such data for patients with cancer. Extracted phenotypes will be used in three ongoing translational studies with a precision medicine focus. Dissemination of the software will enhance the ability of cancer researchers to abstract meaningful clinical data for translational research. If successful, systematic capture and representation of these phenotypes from EMR data could later be used to drive clinical genomic decision support.
Who We Are
- Boston Childrens Hospital/Harvard Medical School
- Guergana Savova (MPI)
- Dmitriy Dligach
- Timothy Miller
- Sean Finan
- David Harris
- Chen Lin
- University of Pittburgh
- Rebecca Crowley Jacobson (MPI)
- Harry Hochheiser
- Roger Day
- Adrian Lee
- Robert Edwards
- John Kirkwood
- Kevin Mitchell
- Eugene Tseytlin
- Girish Chavan
- Liz Legowski (through Jan 2015)
- Melissa Castine
The project described is supported by Grant Number 1U24CA184407-01 from the National Cancer Institute at the US National Institutes of Health. This work is part of the NCI's Informatics Technology for Cancer Research (ITCR) Initiative (http://itcr.nci.nih.gov/) The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
The project period is May 2014 - April, 2019.
Publications and presentations crediting DeepPhe
- Hochheiser H; Jacobson R; Washington N; Denny J; Savova G. 2015. Natural language processing for phenotype extraction: challenges and representation. AMIA Annual Symposium. Nov 2015, San Francisco, CA.
- Dmitriy Dligach, Timothy Miller, Guergana K. Savova. 2015. Semi-supervised Learning for Phenotyping Tasks. AMIA Annual Symposium. Nov 2015, San Francisco, CA.
- Chen, Lin; Dligach, Dmitriy; Miller, Timothy; Bethard, Steven; Savova, Guergana. 2015. Layered temporal modeling for the clinical domain. Journal of the American Medical Informatics Association. http://jamia.oxfordjournals.org/content/early/2015/10/31/jamia.ocv113
DeepPhe software components will also be deployed in the TIES Software System for sharing and accessing deidentified NLP-processed data with tissue(http://ties.pitt.edu/) which is deployed as part of the TIES Cancer Tissue Network (TCRN) across multiple US Cancer Centers.
DeepPhe software development will be coordinated as per software development policies.
DeepPhe software documentation for developers is available in
DeepPhe Gold Set
- Process for Deidentification of Source Documents.
- Process for Deidentification of Source Documents.
- Process for Selection of Gold Set Source Documents.
- Training/Development/Test splits
- training set: all documents for Breast Cancer patients 03, 11, 92, 93 for a total of 48 documents
- development set: all documents for Breast Cancer patients 02, 21 for a total of 42 documents
- test set: all documents for Breast Cancer patients 01, 16 for a total of 41 documents
- use the training set for developing the algorithms and the development set to report results and error analysis. The test set will be used only for the final evaluation to go in publications.
- Detailed Stakeholder Descriptions.
- Interview Protocol
- Contextual Design Notes
- Notes on interviews with informants
Project materials/ WIKIs to tasks
- Liquid Planner link (project management): https://app.liquidplanner.com/space/26220/dashboard
- Templates for describing stakeholders.
- Software development policies and repositories.
- Data Repository and Policies.
- Adopted Standards and Conventions for NLP annotations (task 1.4.2)
- Gold Set Selection
- Phenotyping Rules
- Cancer phenotype modeling notes
- Layered cancer phenotyping
- FHIR modeling
- Domain Modeling Notes/Questions
- Validation of models with domain experts
- Competency questions to be used for validation of models.
- Representations of the models.
- Historical pages
- CEM Cancer phenotype models: models describing the original CEM Models
- Value decomposition issues https://docs.google.com/document/d/1riAHoLRdEmp4Ah9Z8NXN-ABkcAW9nnfNXQ5_md5rgYs/edit
- Visual Analytics
- Informant Interviews
- Technical Infrastructure
- Deep Learning
- Cross document coreference
- Summarization Logic
- Software Best Practices
- Gold standard annotations
- Year 2 goals
- RESEARCH: Coreference
- RESEARCH: Relation extraction
- RESEARCH: Temporal relations
- RESEARCH: Human-Computer interaction
- RESEARCH: BiRADS
- Demo in June 2016
- How to effectively use LiquidPlanner for DeepPhe: https://www.dropbox.com/s/1f6nkhx3yxh4v9q/LiquidPlanner%20for%20Deep-Phe.pptx
- DeepPhe Rule Driven Architectures: https://www.dropbox.com/s/hl70zkvjs1ftt5a/DeepPhe%20Rule%20Driven%20Architectures.pptx
- Bi-weekly team meetings
- Tools we use for communication are listed in our Communications Plan .
- Our Scrum Process
- Sprint Story Boards
- Standup Form
- Sprint 1
- Sprint 2
- Sprint 3
- Sprint 4
- Sprint 5
- Sprint 6
- Sprint 7
- Sprint 8
- Sprint 9, Feb 9 - March 15, 2016
- Sprint 10, March 15 - April 12, 2016
- Sprint 11, April 13 - May 10, 2016
- August 27, 2015 Research Meeting
- August 3, 2015 Modeling Meeting
- July 20, 2015 Modeling Meeting
- July 7, 2015 Bi-weekly team meeting
- July 1, 2015 Scrum Sprint - 1
- June 26, 2015 Software architecture meeting
- June 23, 2015 Bi-weekly team meeting
- June 9, 2015 Bi-weekly team meeting
- May 12, 2015 Team meeting:DeepPhe demo
- May 5, 2015 Team meeting:DeepPhe demo
- April 28, 2015 Bi-weekly team meeting
- April 13, 2015 Bi-weekly team meeting
- March 17, 2015 Bi-weekly team meeting
- February 23, 2015 Model prioritization meeting
- February 17, 2015 Bi-weekly team meeting
- February 3, 2015 Bi-weekly team meeting
- January 28, 2015 BCH team meeting
- January 20, 2015 Bi-weekly team meeting
- January 6, 2015 Bi-weekly team meeting
- December 9, 2014 BCH team meeting
- December 9, 2014 Bi-weekly team meeting
- November 20, 2014 BCH team meeting
- November 11, 2014 Bi-weekly team meeting
- November 11, 2014 BCH team meeting
- November 4, 2014 BCH team meeting
- November 3, 2014 PI meeting
- October 27, 2014 Bi-weekly team meeting: Avillach's presentation on tranSMART, cTAKES and PCORI
- October 14, 2014 Bi-weekly team meeting: agenda and notes
- September 30, 2014 Bi-weekly team meeting: agenda and notes
- September 2, 2014 Bi-weekly team meeting: agenda and notes
- August 19, 2014 Bi-weekly team meeting: agenda and notes
- August 5, 2014 Bi-weekly team meeting: agenda and notes
- July 22, 2014 Bi-weekly team meeting: agenda and notes
- July 15, 2014 Bi-weekly team meeting: agenda and notes
- July 10, 2014 Hochheiser visit to Savova group
- June 24, 2014 Bi-weekly team meeting: agenda and notes
- June 10, 2014 Bi-weekly team meeting: agenda and notes
- June 3, 2014 All hands kick-off meeting
- May 08, 2014 NCIP collaboration with UT (Bermstram/Xu)
Licensing policies for DeepPhe software and ontological models.
If you need assistance and/or if you have questions about the project, feel free to send e-mail to Guergana.Savova at childrens dot harvard dot edu or to Rebecca Crowley Jacobson at rebeccaj at pitt dot edu
Consult the User's Guide for information on using the wiki software.